Author

S. Rajendran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Plant Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 3 Assay:imaging· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Canella· 2 shared E. R. Mardis· 2 shared G. Nigita· 2 shared P. Rajappa· 2 shared A. Cohen-Gadol· 1 shared A. Farfel· 1 shared A. Gross· 1 shared A. Haffey· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

A. Canella

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity

Q. Xie, Y. Du, S. Ghosh, S. Rajendran, A. Cohen-Gadol, M. Baizabal, K. P. Nephew, L. Han, J. Shen

This study identifies H3K9me3 methyltransferases as key drivers in glioblastoma, showing their association with prognosis, immune response, and drug response through multi-omics analysis.

bioRxiv · Apr 18, 2024Cancer Biology

A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels

S. Sinha, B. Callow, A. Farfel, S. Roy, S. Chen, S. Rajendran, J. Buschhaus, K. E. Luker, P. Ghosh, G. D. Luker

This study identifies GIV as a key protein transferred from mesenchymal stromal cells to ER+ breast cancer cells via tunnelling nanotubes, driving aggressive tumor phenotypes.

bioRxiv · Mar 18, 2023Cancer Biology

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumormicroenvironment

A. Canella, M. Nazzaro, S. Rajendran, C. Schmitt, A. Haffey, G. Nigita, D. Thomas, H. Wrightnour, P. Fadda, E. R. Mardis, T. P. Cripe, P. Rajappa

This study shows that genetically modified myeloid cells releasing IL-2 can reprogram the glioma tumor microenvironment to enhance anti-tumor immunity in a mouse model.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

Newly discovered alleles of the tomato antiflorigen gene SELF PRUNING provide a range of plant compactness and yield

M.-S. Kang, Y. J. Kim, J. Heo, S. Rajendran, X. Wang, J. H. Bae, Z. Lippman, S. J. Park

The paper identifies new alleles of the tomato SELF PRUNING gene that alter plant compactness and yield, with sp-5732 increasing yield by up to 42%.

bioRxiv · Apr 17, 2022 · PreprintPlant Biology

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

S. Rajendran, C. Peterson, A. Canella, Y. Hu, A. Gross, M. Cam, A. Serin Harmanci, R. Distefano, G. Nigita, W. Wang, K. E. Miller, O. Elemento, R. D. Roberts, E. C. Holland, G. Rao, , P. Rajappa

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

HistoClean: Open-source Software for Histological Image Pre-processing and Augmentation to Improve Development of Robust Convolutional Neural Networks

K. D. McCombe, S. G. Craig, A. V. Pulsawatdi, J. I. Quezada-Marin, M. Hagan, S. Rajendran, M. P. Humphries, V. Bingham, M. Salto-Tellez, R. Gault, J. A. James

HistoClean is an open-source tool for histological image pre-processing and augmentation to enhance the robustness of convolutional neural networks in detecting stromal maturity.

bioRxiv · Jun 7, 2021Cancer Biology

Resistance to tembotrione, a 4-hydroxyphenylpyruvate dioxygenase-inhibitor, in Sorghum bicolor

B. A. Pandian, A. Varanasi, A. R. Vennapusa, S. Rajendran, G. Lin, M. Zhao, M. Tunnell, T. Tesso, S. Liu, P. V. V. Prasad, M. Jugulam

This study identifies tembotrione-resistant sorghum genotypes, characterizes their resistance mechanism, and maps quantitative trait loci (QTLs) associated with metabolic resistance to this herbicide.

bioRxiv · Jul 29, 2020Plant Biology

Overexpression of HLA class I predominantly on alpha cell in at risk individuals for type 1 diabetes

M. A. Benkahla, S. Sabouri, W. B. Kiosses, S. Rajendran, E. Quesada-Masachs, M. G. von Herrath

This study shows HLA-I hyper-expression occurs in islets of autoantibody-positive donors before T1D diagnosis and is predominantly on alpha cells.

bioRxiv · Jul 13, 2020Immunology