Oxidized phospholipid oxPAPC induces a Th1-like phenotype in regulatory T cells and inhibits their protective function in atherosclerosis
B. D. Appleton, S. A. Palmer, H. Smith, L. E. Stephens, A. S. Major
This study shows that oxPAPC induces a Th1-like phenotype in Tregs, reduces their viability, and impairs their ability to suppress atherosclerosis in mice.
bioRxiv · Feb 8, 2023 · PreprintImmunology