Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia
P. Popovics, W. N. Awadallah, S. Kohrt, T. C. Case, N. L. Miller, E. Ricke, W. Huang, M. Ramirez-Solano, Q. Liu, C. M. Vezina, R. J. Matusik, W. A. Ricke, M. M. Grabowska
This study shows that osteopontin (OPN) is more abundant in symptomatic benign prostatic hyperplasia (S-BPH) compared to incidental BPH, and OPN secretion is stimulated by pro-inflammatory cytokines, driving pro-inflammatory gene expression in stromal cells.
bioRxiv · Dec 23, 2019Pathology