Author

D. L. Michell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

N. Francini· 3 shared C. Duvall· 2 shared E. Hoogenboezem· 2 shared K. C. Vickers· 2 shared K. Vickers· 2 shared A. Abdulrahman· 1 shared A. Cavnar· 1 shared A. Faust· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

N. Francini

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

A. Sorets, K. Schwensen, N. Francini, A. Kjar, A. Abdulrahman, A. Shostak, K. Katdare, K. Schoch, R. Cowell, J. Park, A. Ligocki, W. Ford, L. Ventura-Antunes, E. Hoogenboezem, A. Prusky, , E. Lippmann

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

bioRxiv · Jun 9, 2024 · PreprintBioengineering

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

J. M. Colazo, E. N. Hoogenboezem, M. C. Keech, N. Francini, V. Shah, F. Yu, J. H. Lo, A. G. Sorets, J. T. McCune, H. Cho, C. R. DeJulius, D. L. Michell, T. Maerz, K. C. Vickers, K. N. Gibson-Corley, , C. L. Duvall

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

bioRxiv · May 31, 2023 · PreprintBioengineering

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

bioRxiv · Feb 14, 2023 · PreprintBioengineering

Inhibition of miR-22-3p reduces kidney disease associated with systemic lupus erythematosus

D. L. Michell, A. Faust, J. L. Moore, B. D. Appleton, M. Ormseth, M. Ramirez-Solano, Q. Sheng, J. F. Solus, C. M. Stein, K. C. Vickers, A. S. Major

This study shows that inhibiting miR-22-3p reduces lymphocyte accumulation and kidney disease in a mouse model of systemic lupus erythematosus.

bioRxiv · Jan 7, 2019 · PreprintImmunology