Cancer BiologybioRxiv
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
E. Cho, H. J. Lou, L. Kuruvilla…·B. E. E. Turk
This study identifies PPP6C as a MEK phosphatase that negatively regulates ERK signaling by dephosphorylation, with implications for melanoma therapy resistance.
DOI 10.1016/j.celrep.2021.108928