The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
B. E. Oftedal, S. Maio, A. Handel, M. P. White, D. Howie, S. Davis, N. Prevot, I. A. Rota, M. E. Deadman, B. M. Kessler, R. Fisher, N. S. Trede, E. Sezgin, R. M. Maizels, G. A. Hollander
This study shows that the chaperonin CCT8 is essential for T cell maturation, selection, and function by maintaining proteostasis, and its absence impairs immune protection against helminths.
bioRxiv · Aug 11, 2020Immunology