R. M. Maizels

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

The paper identifies three HpARI family members in H. polygyrus bakeri, showing they have distinct effects on IL-33-dependent Type 2 immune responses.

This study shows that PD-1 signaling regulates Th2 cell metabolism and IL-33 receptor expression through fatty acid oxidation, suggesting PD-1 blockade could treat Th2-related diseases.

This study shows that exogenous TGFβ1 and its mimic HpTGM reduce inflammation and infarct size after myocardial infarction, improving cardiac outcomes.

This study shows that TGM, a helminth-derived TGF-β mimic, accelerates wound healing and reprograms macrophage activation through TGF-β receptor interactions.

This study shows IL-10 promotes Th2 responses and suppresses IFNγ in intestinal helminth infection by regulating Th1 cells.

This study shows that the chaperonin CCT8 is essential for T cell maturation, selection, and function by maintaining proteostasis, and its absence impairs immune protection against helminths.