Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1
F. Byfield, B. Eftekhari, K. Kaymak-Loveless, K. Mandal, D. Li, R. G. Wells, W. Chen, J. Brujic, G. Bergamasschi, G. G. wuite, A. E. Patteson, P. A. Janmey
This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.
bioRxiv · Apr 12, 2024Cell Biology