R. G. Wells

The paper identifies microcystin-RR as a biliary toxin that selectively damages neonatal cholangiocytes through redox stress mechanisms.

This paper develops a vascularized bile duct-on-a-chip model to study PSC, showing PSC cholangiocytes exhibit increased inflammation under IL-17A stimulation.

This study shows that prenatal exposure to low-dose biliatresone in mice leads to altered bile metabolism and liver inflammation in offspring without histological damage.

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

This study examines changes in Glisson's capsule in liver disease, finding increased thickness and cellularity in cirrhosis regardless of cause, altered matrix composition, and reduced mechanical stiffness.

This study shows lipid droplets act as intracellular mechanical stressors that cause nuclear deformation and hepatocyte dedifferentiation, similar to tissue stiffening effects.

The paper examines how fat accumulation in livers with simple steatosis affects liver stiffness, finding that fat softens the liver locally rather than uniformly.

This study identifies versican as a collagen-binding protein that regulates collagen matrix organization and mechanics through its G3 domain.

This study shows that bile acid exposure causes cholangiocyte injury and fibrosis, with a non-toxic bile acid reducing these effects.

This study shows EFEMP1 is crucial for elastic fiber formation and mechanical properties of the extrahepatic bile duct, with reduced EFEMP1 leading to increased compliance and potential role in biliary atresia.

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

The paper tracks particles and hyaluronic acid to show interstitial spaces are continuous across tissue and organ boundaries in humans.

This study shows that lipid droplets in hepatocytes disrupt mechanosensing by altering YAP nuclear localization and affecting cell spreading and focal adhesions.

This paper develops a bile duct-on-a-chip that mimics bile duct structure and barrier function, enabling studies of cholangiocyte permeability and toxin effects.

This study identifies four key anatomical and functional differences between neonatal and adult mouse extrahepatic bile ducts that may explain their susceptibility to injury.