K. Mandal

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.

A conformationally constrained synthetic peptide efficiently inhibits malaria parasite entry into human red blood cells

The paper describes a synthetic cyclic peptide that inhibits malaria parasite entry into human red blood cells by enhancing receptor binding affinity.

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

Computational and experimental studies of the breathing motion of a protein loop: implications in PfAMA1-PfRON2 late-stage binding event

This study combines computational simulations and experimental assays to investigate how the domain II loop of PfAMA1 influences the binding kinetics of PfRON2, identifying key residues critical for the interaction.

A Chimeric Peptide Inhibits Red Blood Cell Invasion by Plasmodium falciparum with Hundredfold Increased Efficacy

The paper designs a chimeric peptide that inhibits Plasmodium falciparum red blood cell invasion with 100x higher efficacy than its parent peptides.

Rational design of protein-specific folding modifiers

This paper designs a method to create protein-specific folding modifiers using xenonuclei, showing they can accelerate protein refolding by 33% under specific conditions.

Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase

This study shows that a mutation in FANCG causes loss of mitochondrial localization, leading to mitochondrial instability and impaired DNA repair.

Role of a kinesin motor in cancer cell mechanics

This study investigates the role of KIF20A, a kinesin motor protein, in bladder cancer cell mechanics and motility, showing that its inhibition alters intracellular and cortical stiffness.