Mutational processes impact the evolution of anti-EGFR antibody resistance in colorectal cancer
A. Woolston, L. J. Barber, B. Griffiths, N. Matthews, S. Rao, D. Watkins, I. Chau, N. Starling, D. Cunningham, M. Gerlinger
The paper investigates mutational processes in colorectal cancer resistance to anti-EGFR antibodies, finding that mutational Signature 17 predicts resistance evolution and shorter progression-free survival.
bioRxiv · May 7, 2020Cancer Biology