Author

K. Fenwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Woolston· 2 shared K. von Loga· 2 shared L. J. Barber· 2 shared M. Gerlinger· 2 shared S. Guettler· 2 shared A. Ashworth· 1 shared A. Drean· 1 shared A. Marx· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. Woolston

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Author profile →

3 papers

Recent·Most cited

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

B. R. Challoner, A. Woolston, D. Lau, M. Buzzetti, C. Fong, L. J. Barber, G. Anandappa, R. Crux, I. Assiotis, K. Fenwick, R. Begum, D. Begum, T. Lund, N. Sivamanoharan, H. B. Sansano, , M. Gerlinger

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

K. von Loga, A. Woolston, M. Punta, L. J. Barber, B. Griffiths, M. Semiannikova, G. J. Spain, B. Challoner, K. Fenwick, H. Schiffmann, A. Marx, G. Sauter, S. Lise, N. Matthews, M. Gerlinger

This study investigates the evolution of mismatch repair deficient gastro-oesophageal cancers using multi-region exome sequencing, revealing extreme intratumour heterogeneity and key genetic events.

bioRxiv · Sep 2, 2019Cancer Biology

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

S. J. Pettitt, D. B. Krastev, I. Brandsma, A. Drean, F. Song, R. Aleksandrov, M. I. Harrell, M. Menon, R. Brough, J. Campbell, J. Frankum, M. Ranes, H. N. Pemberton, R. Rafiq, K. Fenwick, , C. J. Lord

The paper identifies PARP1 point mutations causing PARP inhibitor resistance through CRISPR-Cas9 screens and shows their impact on PARP1 trapping and chemotherapy sensitivity.

bioRxiv · Oct 14, 2017Cancer Biology