Author

M. Gerlinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

A. Woolston· 4 shared L. J. Barber· 4 shared B. Griffiths· 3 shared D. Cunningham· 3 shared I. Chau· 3 shared K. von Loga· 3 shared N. Starling· 3 shared D. Watkins· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCancer Biology

A. Woolston

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5 papers

Recent·Most cited

Multifactorial remodeling of the cancer immunopeptidome by interferon gamma

A. Newey, L. Yu, L. Barber, J. Choudhary, M. Bassani-Sternberg, M. Gerlinger

This study identifies factors influencing immunopeptidome remodeling by IFN-gamma in colorectal cancer, revealing proline's role in peptide downregulation on HLA-I.

bioRxiv · Mar 23, 2022 · PreprintCancer Biology

Genetic and immune landscape evolution defines subtypes of MMR deficient colorectal cancer

B. R. Challoner, A. Woolston, D. Lau, M. Buzzetti, C. Fong, L. J. Barber, G. Anandappa, R. Crux, I. Assiotis, K. Fenwick, R. Begum, D. Begum, T. Lund, N. Sivamanoharan, H. B. Sansano, , M. Gerlinger

The paper identifies three subtypes of MMR deficient colorectal cancer based on genetic and immune landscape evolution, linking them to T-cell infiltrates and checkpoint-inhibitor resistance.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Mutational processes impact the evolution of anti-EGFR antibody resistance in colorectal cancer

A. Woolston, L. J. Barber, B. Griffiths, N. Matthews, S. Rao, D. Watkins, I. Chau, N. Starling, D. Cunningham, M. Gerlinger

The paper investigates mutational processes in colorectal cancer resistance to anti-EGFR antibodies, finding that mutational Signature 17 predicts resistance evolution and shorter progression-free survival.

bioRxiv · May 7, 2020Cancer Biology

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

K. von Loga, A. Woolston, M. Punta, L. J. Barber, B. Griffiths, M. Semiannikova, G. J. Spain, B. Challoner, K. Fenwick, H. Schiffmann, A. Marx, G. Sauter, S. Lise, N. Matthews, M. Gerlinger

This study investigates the evolution of mismatch repair deficient gastro-oesophageal cancers using multi-region exome sequencing, revealing extreme intratumour heterogeneity and key genetic events.

bioRxiv · Sep 2, 2019Cancer Biology

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

A. Woolston, K. Khan, G. Spain, L. J. Barber, B. Griffiths, R. Gonzalez Exposito, Y. Patil, S. Mansukhani, M. N. Davies, A. Furness, F. Sclafani, C. Peckitt, K. Kouvelakis, R. Ranftl, R. Begum, , M. Gerlinger

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

bioRxiv · Oct 19, 2018Cancer Biology