Author

N. Matthews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2 Research Focus:clustering· 1

Frequent Co-Authors

A. Woolston· 2 shared B. Griffiths· 2 shared L. J. Barber· 2 shared M. Gerlinger· 2 shared R. Chauhan· 2 shared A. Antoniou· 1 shared A. Banerjee· 1 shared A. Barreiro Alonso· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Woolston

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

V. Roulstone, J. Kyula, J. Wright, L. Yu, A. Barreiro Alonso, M. Melake, J. Choudhary, R. Elliott, C. J. Lord, D. Mansfield, N. Matthews, R. Chauhan, V. Jennings, C. Chan, H. Baldock, , K. J. Harrington

bioRxiv · Sep 28, 2022 · PreprintCancer Biology

Mutational processes impact the evolution of anti-EGFR antibody resistance in colorectal cancer

A. Woolston, L. J. Barber, B. Griffiths, N. Matthews, S. Rao, D. Watkins, I. Chau, N. Starling, D. Cunningham, M. Gerlinger

The paper investigates mutational processes in colorectal cancer resistance to anti-EGFR antibodies, finding that mutational Signature 17 predicts resistance evolution and shorter progression-free survival.

bioRxiv · May 7, 2020Cancer Biology

Negative selection may cause grossly altered but broadly stable karyotypes in metastatic colorectal cancer

W. Cross, S. Nowinski, G. Cresswell, M. Mossner, A. Banerjee, B. Lu, M. Williams, G. Vlachogiannis, L. Gay, A.-M. Baker, C. Kimberley, F. Whiting, H. Belnoue-Davis, P. Martinez, M. Traki, , Wat

This study analyzes longitudinal genomic data from colorectal cancer patients to show that negative selection stabilizes karyotypes during tumor progression and metastasis.

bioRxiv · Mar 26, 2020 · PreprintCancer Biology

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

K. von Loga, A. Woolston, M. Punta, L. J. Barber, B. Griffiths, M. Semiannikova, G. J. Spain, B. Challoner, K. Fenwick, H. Schiffmann, A. Marx, G. Sauter, S. Lise, N. Matthews, M. Gerlinger

This study investigates the evolution of mismatch repair deficient gastro-oesophageal cancers using multi-region exome sequencing, revealing extreme intratumour heterogeneity and key genetic events.

bioRxiv · Sep 2, 2019Cancer Biology