Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
K. von Loga, A. Woolston, M. Punta, L. J. Barber, B. Griffiths, M. Semiannikova, G. J. Spain, B. Challoner, K. Fenwick, H. Schiffmann, A. Marx, G. Sauter, S. Lise, N. Matthews, M. Gerlinger
This study investigates the evolution of mismatch repair deficient gastro-oesophageal cancers using multi-region exome sequencing, revealing extreme intratumour heterogeneity and key genetic events.
bioRxiv · Sep 2, 2019Cancer Biology