BiochemistrybioRxiv
A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
M. J. Ruggiero, S. Malhotra, A. W. Fenton…·B. Hagenbuch
The paper identifies a rheostat position in NTCP where substitutions produce varied functional effects, showing substrate-dependent transport changes and structural stability variations.
DOI 10.1074/jbc.ra120.014889