Author

J. Karanicolas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:human· 4 Approach:statistical model· 4 Approach:deep learning· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

E. A. Golemis· 2 shared I. Bychkov· 2 shared N. Bai· 2 shared P. Kirubakaran· 2 shared Y. Boumber· 2 shared A. Deneka· 1 shared A. K. Gupta· 1 shared A. W. Fenton· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

E. A. Golemis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

I. Bychkov, A. Deneka, I. Topchu, R. P. Pangeni, C. Lengner, J. Karanicolas, E. A. Golemis, P. Makhov, Y. Boumber

This study shows MSI2 promotes lung tumorigenesis by enhancing ATM expression and DNA damage response, suggesting MSI2 as a potential therapeutic target in lung cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

N. Bai, Y. Adeshina, I. Bychkov, Y. Xia, R. Gowthaman, S. A. Miller, A. K. Gupta, D. K. Johnson, L. Lan, E. A. Golemis, P. B. Makhov, L. Xu, M. M. Pillai, Y. Boumber, J. Karanicolas

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

bioRxiv · Jan 9, 2023 · PreprintBiochemistry

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

S. Merali, C. Quinn, C. Merali, M. C. Rico, J. Karanicolas, O. Perez-Leal, V. Mischley, S. L. Friedman

This study identifies secreted folate receptor-gamma (FOLR3) as a driver of fibrogenesis in NASH by enhancing TGFβ signaling in hepatic stellate cells.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

Efficient Hit-to-Lead Searching of Kinase Inhibitor Chemical Space via Computational Fragment Merging

G. V. Andrianov, W. J. G. Ong, I. Serebriiskii, J. Karanicolas

This paper introduces a computational method to efficiently search kinase inhibitor chemical space by merging fragments to prioritize analogs with improved potency.

bioRxiv · Jun 1, 2021Biochemistry

A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

M. J. Ruggiero, S. Malhotra, A. W. Fenton, L. Swint-Kruse, J. Karanicolas, B. Hagenbuch

The paper identifies a rheostat position in NTCP where substitutions produce varied functional effects, showing substrate-dependent transport changes and structural stability variations.

bioRxiv · Jul 2, 2020Biochemistry

Comparative Modeling of CDK9 Inhibitors to Explore Selectivity and Structure-Activity Relationships

P. Kirubakaran, G. Morton, P. Zhang, H. Zhang, J. Gordon, M. Abou-Gharbia, J.-P. J. Issa, J. Wu, W. Childers, J. Karanicolas

The paper develops a comparative modeling approach to study CDK9 inhibitor selectivity and structure-activity relationships, using existing PDB data and validating with a crystal structure.

bioRxiv · Jun 8, 2020 · PreprintCancer Biology

Rationalizing PROTAC-mediated ternary complex formation using Rosetta

N. Bai, P. Kirubakaran, J. Karanicolas

This paper introduces a computational method using Rosetta to model PROTAC ternary complex formation, showing it can explain PROTAC activity and selectivity without requiring extensive experimental testing.

bioRxiv · May 27, 2020Biochemistry