B. Heames

High-throughput selection of human de novo-emerged sORFs with high folding potential

This study identifies human de novo proteins with high folding potential by screening for structural compactness and disorder using FRET and FACS.

Experimental characterisation of de novoproteins and their unevolved random-sequencecounterparts

The paper experimentally compares de novo proteins and synthetic random-sequence proteins to assess their solubility and structure propensity, finding de novo proteins are more soluble.

Structural and functional characterization of a putative de novo gene in Drosophila

The paper characterizes a de novo gene in Drosophila, showing its structural features and role in male fertility through biochemical and evolutionary analyses.

Access to unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis

This study introduces TRIAD, a transposon mutagenesis method to generate InDels for directed enzyme evolution, showing distinct functional outcomes compared to point mutagenesis.