Author

E. Kay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biochemistry· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

S. Zanivan· 2 shared A. Alekseenko· 1 shared A. Crnjar· 1 shared A. Dell· 1 shared A. M. Cuadros· 1 shared A. Malliri· 1 shared A. Moir· 1 shared A. Montagne· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

S. Zanivan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dual control of host actin polymerization by a Legionella effector pair

M. Pillon, C. Michard, N. Baïlo, J. Bougnon, K. Picq, O. Dubois, C. Andrea, L. Attaiech, V. Daubin, S. Jarraud, E. Kay, P. Doublet

This study identifies LegK2 and VipA as antagonistic effectors in Legionella pneumophila that regulate actin polymerization and bacterial virulence through distinct substrates.

bioRxiv · May 15, 2023Microbiology

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

P. Altea-Manzano, G. Doglioni, A. M. Cuadros, E. Nolan, J. Fernandez-Garcia, Q. Wu, F. Cidre-Aranaz, A. Montagne, M. Planque, O. Marin-Bejar, J. Van Elsen, I. Vermeire, D. Broekaert, C. Riera-Domingo, F. Richard, , S.-M. Fendt

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

bioRxiv · Oct 24, 2022Cancer Biology

Development of a novel glycoengineering platform for the rapid production of conjugate vaccines.

S. Abouelhadid, E. Atkins, E. Kay, I. Passmore, S. J. North, B. Lehri, P. Hitchen, E. Bakke, M. Rahman, J. Bosse, Y. Li, V. S. Terra, P. Langford, A. Dell, B. W. Wren, J. Cuccui

This paper develops a novel glycoengineering platform, MAGIC, which increases glycoconjugate yield and enables vaccine development in genetically intractable bacteria.

bioRxiv · Nov 25, 2021Microbiology

Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling

F. Rossi, A. Crnjar, F. Comitani, R. Feliciano, L. Jahn, G. Malim, L. Southgate, E. Kay, R. Oakey, R. Buggs, A. Moir, L. Kistler, A. Rodriguez Mateos, C. Molteni, R. Schulz

This study assesses the feasibility of genome-wide DNA methylation profiling from oak heartwood, finding that older samples are challenging due to DNA degradation and phenolic compounds.

bioRxiv · Aug 4, 2021Plant Biology

Ultraviolet light-induced collagen degradation inhibits melanoma invasion

T. Budden, C. Gaudy-Marqueste, A. Porter, E. Kay, S. Gurung, C. Earnshaw, K. Roeck, S. Craig, V. Traves, J. Krutmann, P. Muller, L. Motta, S. Zanivan, A. Malliri, S. Furney, , A. Viros

This study shows UVR-induced collagen degradation by fibroblasts reduces melanoma invasion and improves survival, but melanoma-associated fibroblasts can restore invasion by increasing collagen synthesis.

bioRxiv · Jan 27, 2021Cancer Biology

Access to unexplored regions of sequence space in directed enzyme evolution via insertion/deletion mutagenesis

S. Emond, M. Petek, E. Kay, B. Heames, S. Devenish, N. Tokuriki, F. Hollfelder

This study introduces TRIAD, a transposon mutagenesis method to generate InDels for directed enzyme evolution, showing distinct functional outcomes compared to point mutagenesis.

bioRxiv · Oct 10, 2019Biochemistry