Spontaneous polyploids and antimutators compete during the evolution of mutator cells
M. Tracy, M. Lee, B. Hearn, I. Dowsett, L. Thurber, J. Loo, A. M. Loeb, K. Preston, M. Tuncel, N. Ghodsian, A. Bode, T. Tang, A. R. Chia, A. J. Herr
The paper shows that spontaneous polyploids and antimutator clones outcompete each other in mutator yeast cultures, with polyploids dominating in haploid and antimutators in diploid settings.
bioRxiv · May 9, 2020Cancer Biology