The Basal and Major Pilins in the Corynebacterium diphtheriae SpaA Pilus Adopt Similar Structures that Competitively React with the Pilin Polymerase
C. K. Sue, N. A. Cheung, B. J. Mahoney, S. A. McConnell, J. M. Scully, J. Y. Fu, C. Chang, H. Ton-That, J. Loo, R. T. Clubb
The paper shows that SpaB and N-terminal SpaA (NSpaA) from Corynebacterium diphtheriae adopt similar structures and compete for a shared reaction intermediate in pilus assembly.
bioRxiv · Feb 23, 2023Biochemistry