Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
S. Matsuyama, M. Matsuyama, J. Ortega…·W. Greenlee
The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.
J. T. Ortega, A. G. McKee, F. J. Roushar…·B. Jastrzebska
This study identifies a chromenone derivative that stabilizes rod opsin mutants, rescues membrane trafficking in vitro, and protects photoreceptors in vivo in RP models.
F. J. Roushar, A. G. McKee, C. P. Kuntz…·J. P. Schlebach
This study uses deep mutational scanning to analyze how 123 pathogenic rhodopsin variants respond to 9-cis-retinal, identifying variants with diminished membrane expression and varying sensitivity to retinal.
A. G. McKee, C. P. Kuntz, J. T. Ortega…·J. P. Schlebach
This study uses deep mutational scanning to analyze how temperature and retinal affect plasma membrane expression of rhodopsin variants, revealing correlations between mutation sites and sensitivity to these factors.