A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
P. Martinelli, B. Kloesch, N. Hruschka, V. Ionasz, R. Oellinger, S. Mueller, J. Martinez de Villareal, H. P. Dienes, M. Schindl, E. Gruber, J. Stift, G. A. Lomberk, B. Seidler, D. Saur, R. Rad, , F. X. Real
This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.
Gut · Apr 12, 2021Peer-reviewedCancer Biology