Author

P. Martinelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 1

Frequent Co-Authors

F. X. Real· 3 shared N. Hruschka· 2 shared A. Caldeira-Brant· 1 shared A. De Reynies· 1 shared A. Lluch· 1 shared A. M. Schlitter· 1 shared A. Pereira· 1 shared A. Prat· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

F. X. Real

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Author profile →

4 papers

Recent·Most cited

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

M. P. de Andres, R. Jackson, C. Pilarsky, A. M. Schlitter, E. Costello, W. Greenhalf, P. Ganeh, T. Knoesel, D. Palmer, P. Ruemmele, W. Weichert, M. Buechler, T. Hackert, J. P. Neoptolemos, N. Malats, , F. X. Real

This study shows that low GATA4 and GATA6 expression in pancreatic ductal adenocarcinoma (PDAC) is linked to worse patient outcomes and loss of the classical tumor phenotype.

bioRxiv · Aug 9, 2021Cancer Biology

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

P. Martinelli, B. Kloesch, N. Hruschka, V. Ionasz, R. Oellinger, S. Mueller, J. Martinez de Villareal, H. P. Dienes, M. Schindl, E. Gruber, J. Stift, G. A. Lomberk, B. Seidler, D. Saur, R. Rad, , F. X. Real

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

Gut · Apr 12, 2021Peer-reviewedCancer Biology

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

N. Hruschka, M. Subijana, O. Grana-Castro, F. Del Cano-Ochoa, L. Pare Brunet, A. Sagrera, A. De Reynies, D. Andreu, J. Sutton, I. Chernukhin, S.-F. Chin, C. Caldas, A. Lluch, O. Burgues, B. Bermejo, , P. Martinelli

The paper investigates the context-dependent oncogenic effects of the GATA3 X308_Splice mutation in breast cancer, showing its differential impact based on hormonal status.

bioRxiv · Jun 8, 2019Cancer Biology

Postnatal development of skeletal muscle in IUGR pigs: morphofunctional phenotype and molecular mechanisms

F. Almeida, A. Pereira, F. Felicioni, A. Caldeira-Brant, D. Magnabosco, F. Bortolozzo, S. Tsoi, M. Dyck, W. Dixon, P. Martinelli, E. Jorge, H. Chiarini-Garcia

This study examines the postnatal skeletal muscle development in IUGR pigs, finding altered fiber composition and gene expression patterns compared to normal weight pigs.

bioRxiv · Jan 18, 2019 · PreprintCell Biology