Author

G. A. Lomberk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

R. A. Urrutia· 4 shared J. L. Iovanna· 3 shared O. Gayet· 2 shared A. Carrier· 1 shared A. El kaoutari· 1 shared A. Gonzalez· 1 shared Angela J. Mathison· 1 shared Anju Thomas· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCancer Biology

R. A. Urrutia

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4 papers

Recent·Most cited

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas

Gareth Pollin, Angela J. Mathison, Thiago M. de Assuncao, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, J. L. Iovanna, Victor X. Jin, R. A. Urrutia, G. A. Lomberk

bioRxiv · Mar 14, 2024Cancer Biology

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

P. Martinelli, B. Kloesch, N. Hruschka, V. Ionasz, R. Oellinger, S. Mueller, J. Martinez de Villareal, H. P. Dienes, M. Schindl, E. Gruber, J. Stift, G. A. Lomberk, B. Seidler, D. Saur, R. Rad, , F. X. Real

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

Gut · Apr 12, 2021Peer-reviewedCancer Biology

Metabolomic profiling of pancreatic adenocarcinoma reveals fundamental clinical features

J. L. IOVANNA, A. El kaoutari, N. Fraunhoffer, O. Hoare, C. Teyssedou, O. Gayet, J. Roques, G. A. Lomberk, R. A. Urrutia, N. J. Dusetti

This study identifies a metabolic signature in pancreatic adenocarcinoma that predicts clinical outcomes and drug resistance, suggesting metabolic targeting as a therapeutic strategy.

bioRxiv · Feb 1, 2021Cancer Biology

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

J. L. Iovanna, P. Santofimia-Castano, W. Lan, J. Bintz, O. Gayet, A. Carrier, G. A. Lomberk, J. l. Neira, A. Gonzalez, R. A. Urrutia, P. Soubeyran

This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.

bioRxiv · Mar 6, 2018Cell Biology