Inhibition of GCN5 decreases skeletal muscle fat metabolism during high fat diet feeding
A. Green, B. L. Perras, H. Zhang, E. Katsyuba, A. Haboush, K. M. Nyarko, D. K. Pandey, A. Nik-Akhtar, D. Ryu, K. J. Menzies, J. Auwerx
This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.
bioRxiv · Oct 18, 2022 · PreprintPhysiology