D. Ryu

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancers

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

Revealing 3D cancer tissue structures using holotomography and virtual hematoxylin and eosin staining via deep learning

This paper develops a 3D virtual H&E staining method using holotomography and deep learning for cancer tissues, validated on colon and gastric cancer samples.

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Label-free histological analysis of retrieved thrombi in acute ischemic stroke using optical diffraction tomography and deep learning

This study uses optical diffraction tomography and deep learning to automate thrombus composition analysis in acute ischemic stroke, achieving high accuracy and reducing labor.

Inhibition of GCN5 decreases skeletal muscle fat metabolism during high fat diet feeding

This study shows that eliminating GCN5 in skeletal muscle does not improve mitochondrial content or metabolic markers under high-fat diet conditions, but may influence Pdk4 expression and fat metabolism.

L-threonine mediated DAF-16/HSF-1 activation inhibits ferroptosis and increases healthspan

This study shows L-threonine supplementation increases C. elegans healthspan by inhibiting ferroptosis via DAF-16 and HSF-1 pathways.

Synthetic glabridin derivatives mitigate steatohepatitis in a diet-induced biopsy-confirmed non-alcoholic steatosis hepatitis mouse model through paraoxonase-2

This study shows synthetic glabridin derivatives reduce NASH symptoms in mice by activating autophagy and antioxidant defenses through targeting paraoxonase-2.

Rapid label-free identification of pathogenic bacteria species from a minute quantity 1 exploiting three-dimensional quantitative phase imaging and artificial neural network

This paper develops a framework for rapid bacterial species identification using 3D quantitative phase imaging and artificial neural networks, achieving 99.9% accuracy with single colony-forming units.

Reagent- and actuator-free analysis of individual erythrocytes using three-dimensional quantitative phase imaging and capillary microfluidics

This paper presents a method to analyze individual erythrocytes without reagents or actuators using microfluidics and quantitative phase imaging to measure morphological and biochemical properties.

GCN5 Maintains Muscle Integrity by Acetylating YY1 to Promote Dystrophin Expression

This study shows GCN5 acetylates YY1, reducing its DNA binding and increasing dystrophin expression, which maintains muscle integrity in mice.

Label-free bone marrow white blood cell classification using refractive index tomograms and deep learning

This paper presents a label-free method for classifying bone marrow white blood cells using 3D refractive index tomograms and deep learning, achieving high accuracy in subtype classification.

Data-driven multiplexed microtomography of endogenous subcellular dynamics

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

Ancient recombination events between human herpes simplex viruses

This study identifies ancient recombination events between HSV-1 and HSV-2, revealing two HSV-2 lineages with distinct geographic distributions and recombination patterns.