Author

B. Lacy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

C. L. Durie· 2 shared J. M. Chung· 2 shared M. D. Ohi· 2 shared M. J. Sheedlo· 2 shared A. Pirani· 1 shared B. Byrne· 1 shared C. Brito-Silva· 1 shared D. Paredes-Sabja· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

C. L. Durie

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Strain variation in Clostridioides difficile toxin activity associated with genomic variation at both PaLoc and non-PaLoc loci

K. Saund, A. Pirani, B. Lacy, P. C. Hanna, E. S. Snitkin

This study identifies non-PaLoc genomic variants associated with toxin activity and other in vitro phenotypes in C. difficile using phylogenetic, statistical, and GWAS approaches.

bioRxiv · Dec 8, 2021 · PreprintMicrobiology

Redistribution of the novel C. difficile spore-adherence receptor, E-cadherin, by TcdA and TcdB increases spore-binding to adherens junctions.

P. Castro-Cordova, M. Otto-Medina, N. Montes-Bravo, C. Brito-Silva, B. Lacy, D. Paredes-Sabja

This study shows C. difficile spores bind to E-cadherin on intestinal epithelial cells, and toxins TcdA/TcdB increase spore adherence by disrupting adherens junctions.

bioRxiv · Sep 1, 2021 · PreprintMicrobiology

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

M. J. Sheedlo, J. M. Chung, N. Sawhney, C. L. Durie, T. L. Cover, M. D. Ohi, B. Lacy

The paper uses cryo-EM to reveal the structure of H. pylori T4SS core complex components, showing species-specific arrangements and ratios.

bioRxiv · Sep 1, 2020Microbiology

Structural analysis of the Legionella pneumophila Dot/Icm Type IV Secretion System Core Complex

C. L. Durie, M. J. Sheedlo, J. M. Chung, B. Byrne, M. Su, T. Knight, M. Swanson, B. Lacy, M. D. Ohi

The paper reports the structural analysis of the Legionella pneumophila Dot/Icm T4SS core complex using cryo-EM, revealing its stoichiometry and protein interactions.

bioRxiv · Aug 28, 2020Microbiology