M. Su

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

The paper identifies IL-21-expressing CD4+ T cells in an inflammatory neuropathy mouse model and shows their role in neuropathy development through clonal expansion and CXCR6-mediated infiltration.

Initial amino acid:codon assignments and strength of codon:anticodon binding

The paper investigates codon:anticodon binding strengths and suggests that family box codons may have been used in early peptide synthesis due to tighter binding and simultaneous codon recognition.

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

This study identifies VPS13B's localization at the cis-trans Golgi interface and shows its functional interaction with FAM177A1 in lipid transport and Golgi dynamics.

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves

This study investigates the interplay between formins and Arp2/3 complex in cortical actin wave dynamics, revealing both cooperation and antagonism regulated by Cdc42.

Hypoxia-sensing by the Histone Demethylase UTX (KDM6A) Controls Colitogenic CD4+ T cell Fate and Mucosal Inflammation

This study shows that UTX, an oxygen-sensitive histone demethylase, modulates colitis severity by affecting CD4+ T cell function and epigenetic regulation under hypoxia.

Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1

This study investigates the collective dynamics of formin and microtubule networks, revealing FHDC1's role in regulating actin wave nucleation and its crosstalk with microtubules.

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors.

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

Unraveling cellular complexity with unlimited multiplexed super-resolution imaging

This paper introduces FLASH-PAINT, a method for rapid multiplexed super-resolution imaging of many molecular targets in mammalian cells, demonstrating its application in four cell biological studies.

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

A novel inovirus reprograms metabolism and motility of marine Alteromonas

This study isolates and characterizes a novel inovirus, {phi}AFP1, from Alteromonas abrolhosensis, revealing its impact on host metabolism and motility through transcriptomic analysis.

Benzo(a)pyrene regulates chaperone-mediated autophagy via heat shock protein 90

This study shows that benzo(a)pyrene induces chaperone-mediated autophagy (CMA) and DNA damage through heat shock protein 90 (HSP90) in lung cells.

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

Structural and mechanistic basis of σ-dependent transcriptional pausing

This paper identifies the structural basis of σ-dependent transcriptional pausing by showing that it involves backtracked or scrunched states of RNA polymerase, depending on the presence of GreB.

Embracing enzyme promiscuity with activity-based compressed biosensing

This paper introduces SLICE, a method to select promiscuous protease substrates for compressed sensing, enabling accurate classification of complex protease mixtures with fewer substrates.

Molecular basis for the R-type anion channel QUAC1 activity in guard cells

This study determines the cryo-EM structure of QUAC1, an R-type anion channel, revealing its dimeric architecture and mechanism of malate-mediated activation.

Symbiotic bacterial community of Drosophila melanogaster changes with nutritional modifications of the diet but can alleviate negative effects on larval phenotypes

This study shows that dietary changes in Drosophila melanogaster alter their gut microbiota composition and can be mitigated by symbiotic bacteria, improving larval survival and reducing triglyceride levels.

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

Developing a broadly applicable pyrF-based genetic manipulation system in Acinetobacter baumannii

This paper develops a pyrF-based genetic manipulation system for Acinetobacter baumannii, enabling efficient marker-less gene editing in multiple strains.

Transcriptome analysis reveals the main metabolic pathway of c-GMP induced by salt stress in tomato seedlings

This study identifies the metabolic pathways regulated by c-GMP in tomato seedlings under salt stress, showing its role in enhancing salt tolerance through changes in gene expression and metabolic profiles.

Structural analysis of the Legionella pneumophila Dot/Icm Type IV Secretion System Core Complex

The paper reports the structural analysis of the Legionella pneumophila Dot/Icm T4SS core complex using cryo-EM, revealing its stoichiometry and protein interactions.

Comparative study of curvature sensing mediated by F-BAR domain and an intrinsically disordered region of FBP17

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

Influence of the lab adopted natural diet and environmental and parental microbiota on life history and metabolic phenotype of Drosophila melanogaster larvae.

This study examines how natural diet, environmental, and parental microbiota influence obesity-related traits in Drosophila larvae, showing significant differences in phenotypes based on diet and microbial exposure.

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

Eurotium cristatum, a new fungi probiotic from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota

This study shows that Eurotium cristatum, a fungi from Fuzhuan brick tea, reduces obesity in mice by altering gut microbiota composition and increasing short-chain fatty acids.

Genetic signatures of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccinees

This paper analyzes the genetic composition of HCMV variants in gB vaccinees and placebo recipients, finding reduced viral shedding and altered viral population dynamics in vaccinated individuals.

goCTF: Geometrically optimized CTF determination for single-particle cryo-EM

goCTF improves 3D reconstruction resolution in single-particle cryo-EM by optimizing focus gradient determination through geometrically enhanced CTF parameter estimation.

High altitude adaptation mitigates anemia risk associated with diabetes among the Mosuo of Southwest China

The paper investigates whether high-altitude adaptations reduce anemia risk in diabetics among the Mosuo population in Southwest China.

Probing the Acyl Carrier Protein-Enzyme Interactions within Terminal Alkyne Biosynthetic Machinery

The paper investigates ACP interactions with alkyne biosynthetic enzymes JamA and JamB, showing JamB has stronger ACP interaction and identifying key ACP residues critical for compatibility with JamB.

Collective membrane dynamics emerging from curvature-dependent spatial coupling

The paper shows membrane curvature drives collective dynamics of cortical proteins through mechanochemical feedback, influencing wave propagation and spatiotemporal patterns.