M. Swanson

Heterogeneous Nuclear Ribonucleoprotein C is an Indispensable Target in Acute Myeloid Leukemia

This study identifies HNRNPC as a critical therapeutic target in AML by showing its role in regulating Myc-Max activity through alternative splicing.

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

This study identifies Mbnl3 as a placenta-specific X-linked gene that restricts placental growth in eutherians through altered RNA binding specificities and novel biological functions.

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

The paper uses cryo-EM to determine the structure of the Legionella pneumophila Dot/Icm T4SS, identifying new proteins and symmetry elements that contribute to its function.

Identification and Characterization of a Residual Host Cell Protein Hexosaminidase B Associated with N-glycan Degradation During the Stability Study of a Therapeutic Recombinant Monoclonal Antibody Product

The paper identifies Hexosaminidase B as a residual host cell protein causing N-glycan degradation in a monoclonal antibody under stability conditions and develops strategies to mitigate its impact.

Structural analysis of the Legionella pneumophila Dot/Icm Type IV Secretion System Core Complex

The paper reports the structural analysis of the Legionella pneumophila Dot/Icm T4SS core complex using cryo-EM, revealing its stoichiometry and protein interactions.

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.