The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes.
J. M. Pemberton, E. J. Osterlund, W. Schoormann, J. Pogmore, D. Nguyen, B. Leber, D. Andrews
This study identifies a novel binding site in PUMA's carboxyl-terminal sequence that contributes to its resistance to BH3-mimetic displacement from anti-apoptotic proteins.
bioRxiv · Apr 2, 2023Cell Biology