Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
T. Zeng, T. Jiang, B. Zhang, T. Zhang, W. Dai, X. Yin, Y. Li, C. Wu, Y. Wu, X. Chi, X. Deng, H.-R. Wang
This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.
bioRxiv · Apr 26, 2024 · PreprintCancer Biology
B. Tan, X. Zhang, A. Ansari, P. Jadhav, H. Tan, K. Li, A. Chopra, A. Ford, X. Chi, F. R. Figueras, E. Arnold, X. Deng, J. Wang
The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.
bioRxiv · Dec 1, 2023Microbiology
X. Chi, L. Xia, G. Zhang, X. Chi, B. Huang, Y. Zhang, Z. Chen, J. Han, L. Wu, Z. Li, H. Sun, P. Huang, C. Yu, W. Chen, Q. Zhou
This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.
bioRxiv · Sep 25, 2022 · PreprintMicrobiology
X. Chi, X. Zhang, S. Pan, Y. Yu, T. Lin, H. Duan, X. Liu, W. Chen, X. Yang, Q. Ding, J. Wang, W. Yang
This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.
bioRxiv · Dec 25, 2021Microbiology
T. Xie, X. Chi, B. Huang, F. Ye, Q. Zhou, J. Huang
The paper identifies three new folds in the solute carrier superfamily, with one validated experimentally in the SLC44 family, providing insights into structure-function relationships.
bioRxiv · Aug 21, 2021Biophysics
L. Caraballo-Galva, M. Hussein, X. Jiang, H. Zhang, R. Mao, P. Brody, X. Chi, Y. Peng, A. He, M. Kehinge-Ige, R. Sadek, H. Shi, X. Qiu, Y. He
bioRxiv · Jul 9, 2021Immunology
X. Chi, O. O. Ogunsade, Z. Zhou, Z. Li, X. Li, M. Zhang, F. Song, J. Wang, M. A. Hammad, X. Zhang, S. Zhang, X. Wan, L. Zhang, C. Zhang, P. Liu
The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.
bioRxiv · May 18, 2020 · PreprintCell Biology
X. Chi, R. Yan, J. Zhang, G. Zhang, Y. Zhang, M. Hao, Z. Zhang, P. Fan, Y. Dong, Y. Yang, Z. Chen, Y. Guo, J. Zhang, Y. Li, X. Song, , W. Chen
This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.
bioRxiv · May 8, 2020Biochemistry
X. Chi, X. Liu, C. Wang, X. Zhang, L. Ren, Q. Jin, J. Wang, W. Yang
This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.
bioRxiv · Apr 14, 2020Microbiology
X. Chi, X. Li, Y. Chen, Y. Zhang, Q. Su, Q. Zhou
This study presents the structures of human KCC2 and KCC3, including phosphorylation and inhibitor-bound forms, revealing mechanisms of regulation and potential drug targets.
bioRxiv · Feb 22, 2020 · PreprintBiochemistry
X. Chi, D. Gong, K. Ren, G. Zhou, G. Huang, J. Lei, Q. Zhou, N. Yan
The paper reports cryo-EM structures of RyR2 bound to modulators, revealing how Ca2+ and other molecules regulate channel gating and provide insights into cardiac disorder mechanisms.
bioRxiv · Jul 19, 2019Biochemistry
X. Chi, J. Pemberton, D. Nguyen, E. J. Osterlund, Q. Liu, H. Brahmbhatt, Z. Zhang, J. Lin, B. Leber, D. Andrews
This study shows that the carboxyl-terminal sequence of Bim is necessary for Bax activation and cell killing, independent of anti-apoptotic protein inhibition.
bioRxiv · Feb 19, 2019Biochemistry