FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma
G. Orstad, G. Fort, T. J. Parnell, A. Jones, C. Stubben, B. Lohman, K. L. Gillis, W. Orellana, R. Tariq, O. Klingbeil, K. H. Kaestner, C. Vakoc, B. T. Spike, E. L. Snyder
This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.
bioRxiv · Jun 29, 2021 · PreprintCancer Biology