Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
O. Klingbeil, D. Skopelitis, C. Tonelli, A. Alpsoy, F. Minicozzi, D. Aggarwal, S. Russo, T. Ha, O. E. Demerdash, D. L. Spector, D. A. Tuveson, P. Cifani, C. R. Vakoc
This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.
bioRxiv · Feb 26, 2024Cancer Biology
T. He, L. Xiao, Y. Qiao, O. Klingbeil, E. Young, X. S. Wu, R. Mannan, S. Mahapatra, S. Eyunni, J. C.-Y. Tien, X. Wang, Y. Zheng, N. Kim, H. Zheng, S. Hou, , A. M. Chinnaiyan
This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.
bioRxiv · Jan 22, 2024Cancer Biology
C. Tonelli, G. N. Yordanov, Y. Hao, A. Deschenes, O. Klingbeil, H.-C. Ting, E. Brosnan, A. Doshi, Y. Park, C. R. Vakoc, J. Preall, D. Tuveson
The paper identifies SPDEF as a key driver of the classical subtype of pancreatic ductal adenocarcinoma, showing its role in tumor progression and dependence on specific target genes.
bioRxiv · Mar 18, 2022 · PreprintCancer Biology
G. Orstad, G. Fort, T. J. Parnell, A. Jones, C. Stubben, B. Lohman, K. L. Gillis, W. Orellana, R. Tariq, O. Klingbeil, K. H. Kaestner, C. Vakoc, B. T. Spike, E. L. Snyder
This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.
bioRxiv · Jun 29, 2021 · PreprintCancer Biology
S. A. Polyanskaya, R. Y. Moreno, B. Lu, R. Feng, Y. Yao, S. Irani, O. Klingbeil, Z. Yang, Y. Wei, O. E. Demerdash, L. A. Benjamin, M. J. Weiss, Y. Zhang, C. R. Vakoc
This study identifies the SCP4-STK35/PDIK1L phosphatase-kinase complex as a critical signaling dependency in AML, showing its role in proliferation and amino acid metabolism through dual regulatory mechanisms.
bioRxiv · May 9, 2021Cancer Biology
Y. Wei, S. Iyer, S. Costa, Z. Yang, M. Kramer, E. Adelman, O. Klingbeil, O. Demerdash, S. Polyanskaya, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. Figueroa, C. Vakoc
The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.
bioRxiv · Dec 22, 2020 · PreprintCancer Biology
Z. Yang, Y. Wei, X. S. Wu, S. V. Iyer, M. Jung, E. R. Adelman, O. Klingbeil, M. Kramer, O. E. Demerdash, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. E. Figueroa, A. Smogorzewska, C. R. Vakoc
This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.
bioRxiv · Oct 23, 2020Cancer Biology
T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc
This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.
bioRxiv · Nov 6, 2019Cancer Biology