B. T. Spike

OCA-B promotes pathogenic maturation 1 of stem-like CD4+ T cells and autoimmune demyelination

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

Mcam stabilizes luminal progenitor breast cancer phenotypes via Ck2 control and Src/Akt/Stat3 attenuation

This study shows Mcam stabilizes luminal progenitor breast cancer phenotypes by regulating Ck2 and attenuating Stat3, Src/Akt/Stat3 signaling, and cell state transitions.

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

This study uses multiparametric quantitative phase imaging to assess drug response in breast cancer cells, revealing single-cell heterogeneity and resistance dynamics.

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma