BiochemistrybioRxiv
benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes
S. Murthy, M. G. Nizi, M. M. Maksimainen…·L. Lehtiö
The paper identifies a benzothiazole scaffold that inhibits multiple PARP enzymes with nanomolar potency, showing selectivity for mono-ARTs and poly-ARTs.
DOI 10.1021/acs.jmedchem.2c01460