S. Murthy

Whole genome sequencing and comparative genomic studies of Priestia filamentosa JURBA-X for its drought-tolerance, plant-growth promotion, and fluorescent characteristics

This study sequenced and compared the genome of Priestia filamentosa JURBA-X, identifying its drought tolerance, plant growth promotion, and fluorescent properties linked to resistomycin production.

Light management by algal aggregates in living photosynthetic hydrogels.

This study investigates how algal aggregates in hydrogels improve light distribution and biomass growth by reducing photoinhibition and increasing light penetration.

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

Zoledronic acid improves bone quality and muscle function in a high bone turnover state

This study shows zoledronic acid improves bone quality and muscle function in a mouse model of metabolic bone disease by reducing TGFβ release from bone.

Live tracking of a plant pathogen outbreak reveals rapid and successive, multidecade episome reduction

The paper tracks a 2022 plant pathogen outbreak, revealing a recent genome reduction event in Xanthomonas hortorum through real-time sequencing and historical isolate analysis.

Low-Magnitude Mechanical Signals Combined with Zoledronic Acid Reduce Musculoskeletal Weakness and Adiposity in Estrogen-Deprived Mice

Combining low-intensity vibration with zoledronic acid reduces musculoskeletal weakness and adiposity in estrogen-deprived mice.

Modeling the radiative, thermal and chemical microenvironment of 3D scanned corals

The paper develops a multiphysics model to simulate light, temperature, and O2 microenvironments in 3D scanned corals and validates it against measurements.

Non-invasive investigation of the morphology and optical properties of the upside-down jellyfish Cassiopea with optical coherence tomography

This study uses optical coherence tomography to investigate the morphology and optical properties of Cassiopea jellyfish, showing that white granules enhance light availability for symbionts, leading to increased carbon fixation.

A high-throughput exonuclease assay based on the fluorescent base analog 2-aminopurine

The paper introduces a high-throughput exonuclease assay using 2-aminopurine and identifies a novel inhibitor of Mycobacterium tuberculosis PHP-exonuclease.

benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes

The paper identifies a benzothiazole scaffold that inhibits multiple PARP enzymes with nanomolar potency, showing selectivity for mono-ARTs and poly-ARTs.

Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs

The paper develops TIQ-A analogs that selectively inhibit mono-ADP-ribosyltransferases PARP10 and PARP15 over poly-ADP-ribosyltransferases, achieving 10-20-fold selectivity while maintaining micromolar potency.

Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants

The paper identifies a stretch-activated ion channel in touch-sensitive trigger hairs of carnivorous Droseraceae plants, suggesting it evolved from ancestral mechanosensitive channels.

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

The paper identifies OSCA proteins in plants and their homologues TMEM63 in animals as evolutionarily conserved mechanosensitive ion channels involved in mechanotransduction.

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.