Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
S. Wazir, T. A. O. Parviainen, M. M. Maksimainen…·L. Lehtiö
This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.
S. Murthy, M. G. Nizi, M. M. Maksimainen…·L. Lehtiö
The paper identifies a benzothiazole scaffold that inhibits multiple PARP enzymes with nanomolar potency, showing selectivity for mono-ARTs and poly-ARTs.
M. M. Maksimainen, S. Murthy, S. T. Sowa…·L. Lehtiö
The paper develops TIQ-A analogs that selectively inhibit mono-ADP-ribosyltransferases PARP10 and PARP15 over poly-ADP-ribosyltransferases, achieving 10-20-fold selectivity while maintaining micromolar potency.
S. T. Sowa, A. Galera-Prat, S. Wazir…·L. Lehtio
The paper develops a molecular toolbox for studying ADP-ribosyl binding proteins, including a fusion tag and high-affinity binders, and identifies suramin as an inhibitor of SARS-CoV-2 nsp3 macrodomain.
E. Obaji, M. M. Maksimainen, A. Galera-Prat, L. Lehtio
The paper describes how DNA damage activates ARTD2/PARP2 through conformational changes that relieve autoinhibition and enable catalytic activity.
Y. Ashok, M. M. Maksimainen, T. Kallio…·L. Lehtiö
The paper reports structural analysis of Pediococcus acidilactici lactate oxidase, revealing its FMN-dependent oligomerization and suggesting it may be a misannotated enzyme with unknown oxidation activity.