Reconstitution of the host holobiont in germ-free rats acutely increases bone growth and affects marrow cellular content
P. J. Czernik, R. M. Golonka, S. Chakraborty, B. S. Yeoh, A. Abokor, P. Saha, J. Y. Yeo, B. Mell, X. Cheng, S. Baroi, B. Joe, M. Vijay-Kumar, B. Lecka-Czernik
This study shows that reconstituting the gut microbiota in germ-free rats accelerates bone growth and alters marrow cell composition, with effects linked to increased short-chain fatty acids and IGF-1 levels.
bioRxiv · Jul 15, 2020 · PreprintPhysiology