P. Saha

Predictive and Experimental Motif Interaction Analysis Identifies Functions of the WNK-OSR1/SPAK Pathway

The paper identifies interaction motifs of the WNK-OSR1/SPAK pathway and validates their function through experimental testing.

Crude extract of Ruellia tuberosa L. flower induces intracellular ROS, promotes DNA damage and apoptosis in Triple Negative Breast Cancer Cells

This study shows that the methanolic extract of Ruellia tuberosa L. flower induces ROS, causes G0/G1 cell cycle arrest, and promotes apoptosis in TNBC cells without toxicity in mice.

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

NRP1-expressing myeloid cells promote arteriogenesis in the ischemic limb

The paper identifies NRP1-expressing myeloid cells as promoters of arteriogenesis in ischemic limbs and suggests their therapeutic potential.

Myeloperoxidase activity predicts atherosclerotic plaque disruption and atherothrombosis

This study shows that myeloperoxidase (MPO) activity in atherosclerotic plaques predicts atherothrombosis in rabbits and correlates with ruptured human atheroma.

PROTEOMICS OF HYPOTHERMIC ADAPTATION REVEALS THAT RBM3 ENHANCES MITOCHONDRIAL METABOLISM AND MUSCLE STEM-CELL DIFFERENTIATION

This study identifies RBM3 as a key mediator of hypothermic adaptation in skeletal muscle myoblasts, showing it enhances mitochondrial metabolism and muscle stem-cell differentiation.

Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate

This study identifies a mechanism by which mitochondrial glutamine metabolism links cell cycle progression to stem cell fate decisions through PASK and WDR5 interactions.

Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models

This study shows that microcystin exposure alters the gut resistome and dysregulates immune homeostasis in mice, linking antibiotic resistance genes to immune markers.

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

Reconstitution of the host holobiont in germ-free rats acutely increases bone growth and affects marrow cellular content

This study shows that reconstituting the gut microbiota in germ-free rats accelerates bone growth and alters marrow cell composition, with effects linked to increased short-chain fatty acids and IGF-1 levels.

Comprehensive analysis of genomic diversity of SARS-CoV-2 in different geographic regions of India: An endeavour to classify Indian SARS-CoV-2 strains on the basis of co-existing mutations

This study analyzes SARS-CoV-2 genomic diversity in India, identifying 33 mutations and classifying strains into 22 groups based on co-existing mutations.

A virus that has gone viral: Amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding and thus infectivity

The paper analyzes amino acid mutations in the S protein of Indian SARS-CoV-2 isolates, identifying a mutation at position 407 that may affect receptor binding and infectivity.

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

The paper investigates the role of inter-domain dynamics in cholesterol transport by NPC1 and NPC1L1 proteins, showing that domain movement is essential and that Ezetimibe inhibits NPC1L1 by binding to multiple domains.