Author

B. P. Metzger

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. W. Thornton· 1 shared T. N. Starr· 1 shared Y. Park· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperEvolutionary Biology

J. W. Thornton

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1 paper

Recent·Most cited

Evolutionary BiologybioRxivApr 19, 2023

Epistasis facilitates functional evolution in an ancient transcription factor

B. P. Metzger, Y. Park, T. N. Starr, J. W. Thornton

This study uses combinatorial DMS to analyze the genetic architecture of DNA recognition by an ancient transcription factor, showing that pairwise epistasis enables functional evolution by expanding sequence space for new specificity.

DOI 10.7554/elife.88737

proteomicsstatistical model

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