Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice
R. T. Rydze, B. Patton, H. S. Torralba, S. Briley, G. Gipson, R. James, A. Rajkovic, T. B. Thompson, S. Pangas
This study shows that deleting Grem2 in mice reduces fertility and disrupts estrous cycles, suggesting a role for Grem2 in regulating the HPO axis and female reproductive health.
bioRxiv · Oct 1, 2020Physiology