MicrobiologybioRxivPreprint
Host F-box protein 22 enhances the uptake of Brucella by macrophages and drives a sustained release of pro-inflammatory cytokines through degradation of the anti-inflammatory effector proteins of Brucella.
G. Radhakrishnan, V. Mazumdar, K. Joshi…·V. K. Gupta
This study identifies FBXO22 as a host protein that enhances Brucella uptake by macrophages and promotes pro-inflammatory cytokine release by degrading Brucella anti-inflammatory effectors.
DOI 10.1101/2021.03.15.435452