K. Joshi

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.

Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms

The paper compares stochastic growth and division dynamics of bacterial cells in two microfluidic platforms, finding that mechanical confinement increases interdivision times but is compensated by division ratio adjustments.

Architectural underpinnings of stochastic intergenerational homeostasis

The paper identifies the core mechanism for stochastic intergenerational cell size homeostasis in bacteria using high-precision data and first passage process analysis.

Keras/TensorFlow in Drug Design for Immunity Disorders

This study uses Keras/TensorFlow to enhance structure-based virtual screening for drug discovery targeting chemokine receptors, showing improved prediction of receptor subtype selectivity.

The arginine/ornithine binding protein ArgT plays an essential role in Brucella to prevent intracellular killing and contribute to chronic persistence in the host

This study identifies ArgT as a critical virulence factor in Brucella that prevents intracellular killing and promotes chronic persistence by modulating host arginine levels.

Non-Markovian memory in a bacterium

This study investigates whether bacterial cells retain memory of past environmental conditions across generations, finding non-Markovian memory in growth rates but not cell size.

Brucella targets host USP8 through the effector protein TcpB to facilitate infection of macrophages

This study identifies USP8 as a host target of Brucella effector TcpB, showing that TcpB suppresses USP8 via the CREB pathway to enhance Brucella infection of macrophages.

Emergent periodicity in the collective synchronous flashing of fireflies

This paper studies how fireflies synchronize their flashing in swarms and proposes a mathematical framework to explain the emergence of periodicity without fitting parameters.

Cellular dynamics under time-varying conditions

The paper proposes a temporal scaling model to explain how bacterial cells adjust their age distribution under changing environmental conditions using a time-invariant rule.

Intergenerational scaling law determines the precision kinematics of stochastic individual-cell-size homeostasis

The paper develops a theoretical framework to explain intergenerational stochastic homeostasis in bacterial cell size, validated by experimental data from multiple microorganisms.

Emergent Simplicities in Stochastic Intergenerational Homeostasis

This paper identifies emergent simplicities in intergenerational homeostasis through experiments and theory, revealing a Markovian scaling law that determines stochastic homeostasis without fine-tuning parameters.

Bacterial Strategies for Damage Management

This study develops a mathematical framework to analyze optimal resource partitioning between growth and repair in bacteria, identifying distinct strategies based on degradation rates and organism size.

Compartmentation of putrescine synthesis in plants

This study identifies the subcellular localization of enzymes involved in putrescine synthesis in plants, revealing compartmentalization in chloroplasts, ER, and mitochondria.

Single amino acid residues control potential-dependent inactivation of an inner membrane bc-cytochrome

The paper identifies single amino acid mutations in CbcL that prevent redox potential-dependent inactivation, allowing growth at higher potentials.

Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism

The paper tracks endosomal maturation events using advanced imaging and simulations, revealing that maturation is driven by heterotypic EEA1-mediated interactions rather than autonomous stochastic processes.

Single cells tell their own story: An updated framework for understanding stochastic variations in cell cycle progression in bacteria

The paper introduces a framework to account for stochastic variations in bacterial cell cycle progression using single-cell data and medium composition effects.

Geobacter sulfurreducens inner membrane cytochrome CbcBA controls electron transfer and growth yield near the energetic limit of respiration.

This paper identifies CbcBA as an essential bc-type cytochrome in Geobacter sulfurreducens that regulates electron transfer and growth yield under low redox potential conditions.

Host F-box protein 22 enhances the uptake of Brucella by macrophages and drives a sustained release of pro-inflammatory cytokines through degradation of the anti-inflammatory effector proteins of Brucella.

This study identifies FBXO22 as a host protein that enhances Brucella uptake by macrophages and promotes pro-inflammatory cytokine release by degrading Brucella anti-inflammatory effectors.

LC/MS-QToF Profiling, Anti-Diabetic and Anti-Adipogenic potential of Divya MadhuKalp: A Novel Herbo-mineral Formulation

This study evaluates the anti-diabetic and anti-adipogenic effects of the herbo-mineral formulation Divya MadhuKalp using in vitro and in vivo models.

Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response

This study identifies immune hot and cold tumour subgroups across cancers using DNA methylation-based deconvolution, linking them to immunotherapy response and immune resistance mechanisms.