Adaptation-proof SARS-CoV-2 vaccine design
Y. L. Vishweshwaraiah, B. Hnath, B. Rackley, J. Wang, A. Gontu, M. Chandler, K. A. Afonin, S. V. Kuchipudi, N. Christensen, N. H. Yennawar, N. V. Dokholyan
This study designs SARS-CoV-2 vaccines targeting conserved spike protein regions to reduce mutation escape, using epitope grafting on diverse scaffolds and showing immune response and diagnostic utility.
bioRxiv · May 17, 2022Bioengineering