T.-L. Chew

Distinct mobility patterns of BRCA2 molecules at DNA damage sites

This study quantifies BRCA2 mobility patterns at DNA damage sites using advanced microscopy, revealing immobile and subdiffusive motions that may enhance repair efficiency.

Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle

The paper identifies a novel subcellular architecture where the endoplasmic reticulum interacts with desmosomes and keratin filaments, influencing ER organization and dynamics.

Actin nano-architecture of phagocytic podosomes

The paper uses advanced microscopy techniques to characterize the structure of phagocytic podosomes during frustrated phagocytosis, revealing their unique actin architecture and associated protein distributions.

Campylobacter jejuni trigger signaling through host cell focal adhesions to inhibit cell motility and impede wound repair

This study shows that Campylobacter jejuni manipulates host cell focal adhesions to reduce motility and impair wound repair.

The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo.

A Drosophila model shows that high oncogenic Ras levels drive malignant transformation in Lkb1 mutant tissue, with implications for human lung adenocarcinoma.

The Chlamydia type III effector TarP alters the dynamics and organization of host cell focal adhesions

This study shows that Chlamydia's effector TarP stabilizes focal adhesions by interacting with vinculin, reducing cell motility and enhancing matrix attachment.

Quantitative measurements of chromatin modification dynamics during zygotic genome activation

The paper quantifies chromatin modification dynamics during zygotic genome activation in zebrafish embryos using fluorescent antibody imaging.

An actin-based protrusion originating from a podosome-enrichedregion initiates macrophage fusion

This study identifies actin-based protrusions from podosome-enriched regions as initiators of macrophage fusion in chronic inflammatory diseases.