Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury
M. Redd, S. Scheuer, N. Saez, H. Chiu, L. Gao, M. Hicks, J. Villanueva, G. Cuellar-Partida, J. Peart, L. See Hoe, X. Chen, Y. Sun, J. Suen, R. Hatch, B. Rollo, , N. Palpant
This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.
bioRxiv · Nov 17, 2020Physiology