J. Fraser

Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from FDG yield potent sensors of living bacteria in vivo

This paper develops chemoenzymatic methods to synthesize [18F]-labeled disaccharides from FDG, which detect bacteria in vivo by their specific glycan incorporation.

Design, development, and preliminary assessment of a novel peripheral intravenous catheter aimed at reducing early failure rates

This paper designs a novel peripheral intravenous catheter (FloRamp) to reduce early failure rates and reports preliminary results from animal testing showing reduced occlusion and lower phlebitis scores.

Ensemble-function relationships to evaluate catalysis in the ketosteroid isomerase oxyanion hole

The paper evaluates catalytic effects in ketosteroid isomerase by analyzing ensemble conformations and their functional implications.

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

High-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit and validation of nucleotide modifications

The paper presents a high-resolution cryo-EM structure of E. coli 50S subunit and develops a program for identifying rRNA modifications using cryo-EM maps.

Effects of α-tubulin acetylation on microtubule structure and stability

This study uses cryo-EM and molecular dynamics to show that α-tubulin acetylation at K40 reduces loop disorder and may affect microtubule stability.

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

A multi-model approach to assessing local and global cryo-EM map quality

The paper presents a multi-model approach to assess local and global cryo-EM map quality using independent model generation and convergence analysis.