Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis
C. Xu, D. Fisher, S. Rankovic, W. Li, R. Dick, B. Runge, R. Zadorozhnyi, J. Ahn, C. Aiken, T. Polenova, A. Engelman, Z. Ambrose, I. Rousso, J. R. Perilla
This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.
bioRxiv · Apr 30, 2020Biophysics