J. Ahn

Aeon: an open-source platform to study the neural basis of ethological behaviours over naturalistic timescales

Aeon enables long-term study of ethological behaviours in mice with simultaneous brain activity recording and provides a unified data format for analysis.

Cyclophilin A Facilitates HIV-1 DNA Integration

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.

Gut microbiome is associated with recurrence-free survival in patients with resected Stage IIIB-D or Stage IV melanoma treated with immune checkpoint inhibitors

The paper identifies gut microbiome taxonomic markers associated with recurrence in melanoma patients treated with immune checkpoint inhibitors, showing generalizability across regions when GMB composition is matched.

Fast and lightweight cell atlas approximations across organs and organisms

This paper introduces a computational approach for fast, scalable, and accessible exploration of cell atlases across species using a web interface and APIs.

Maladaptive immune-fibrotic axis drives impaired long bone regeneration under mechanical instability

This study shows that mechanical instability causes fibrosis and immune dysregulation, impairing bone healing in fractures.

Upregulation of the NKG2D ligand ULBP2 by JC polyomavirus infection promotes immune recognition by natural killer cells.

This study shows that NK cells can eliminate JCPyV-infected cells through NKG2D-ULBP2 interaction, suggesting this pathway as a potential immunotherapeutic target for PML.

Comparative evaluation of synthetic cytokines for enhancing production and performance of NK92 cell-based therapies

The paper evaluates synthetic cytokines to enhance NK92 cell production and performance, finding that membrane-bound cytokines improve cytotoxicity and expansion.

Activin A promotes bone fracture repair and acts through a novel myofibroblastic cell population in callus

This study identifies activin A's role in bone fracture repair by promoting a novel myofibroblastic progenitor cell population that drives chondrogenesis and osteogenesis.

Mosquito invasion via the global shipping network is slowed in high-risk areas by on-shore and ship-board monitoring

The paper models mosquito invasion risk via shipping and finds that monitoring containers upon arrival is more effective than onboard eradication.

Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

Microbial Risk Score for Capturing Microbial Characteristics, Integrating Multi-omics Data, and Predicting Disease Risk

The paper introduces a microbial risk score (MRS) framework to aggregate microbiome data into a predictive score for disease risk, validated across multiple cohorts.

Using marine cargo traffic to identify countries in Africa with greatest risk of invasion by Anopheles stephensi

This paper uses maritime trade data to identify African countries most at risk of Anopheles stephensi invasion and prioritizes surveillance efforts based on trade connectivity and habitat suitability.

Targeting properdin - Structure and function of a novel family of tick-derived complement inhibitors

This study identifies and characterizes a novel family of tick-derived complement inhibitors, CirpA, which bind to properdin and inhibit complement activation.

Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids

This study investigates how cardiolipin and phosphatidylglycerol lipids induce structural and dynamic changes in cytochrome c, affecting its peroxidase activity during mitochondrial apoptosis.

Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

Analysis of site and structure specific core fucosylation in liver disease progression using exoglycosidase-assisted data-independent LC-MS/MS

This study quantifies core fucosylation changes in liver disease using mass spectrometry and exoglycosidase-assisted analysis of glycopeptides.

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

CHLOROPLAST UNUSUAL POSITIONING 1 is a new type of actin nucleation factor in plants

This study identifies CHUP1 as a plant-specific actin nucleator involved in chloroplast movement by interacting with cp-actin filaments and responding to blue light.

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environment

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.

Impact of Chronic Total Occlusion Lesion Length onSix-month Angiographic and 2-year Clinical Outcomes

This study compares 6-month angiographic and 2-year clinical outcomes between long and short chronic total occlusion (CTO) lesions after successful DES PCI, finding higher repeat PCI rates in long CTO lesions.